Total serum tryptase: a predictive marker for KIT mutation in acute myeloid leukemia.

  title={Total serum tryptase: a predictive marker for KIT mutation in acute myeloid leukemia.},
  author={Roberto Cairoli and Carla Barbara Ripamonti and Alessandro Beghini and Simonetta Granata and Giovanni Grillo and Matteo Brioschi and Gianpaolo Nadali and Assunta Viola and C Cattaneo and Liliana Inropido and Erika Ravelli and Giambattista Bertani and Laura Pezzetti and Michele Nichelatti and Alessandro Marocchi and Giuseppe Rossi and Giovanni Pizzolo and Felicetto Ferrara and Anna Maria Nosari and Enrica Morra},
  journal={Leukemia research},
  volume={33 9},
Human tryptase is a serine protease expressed in mast-cells. We previously observed that AML blast cells, cultured in vitro from a KIT D816Y patient, give rise to adherent cells with mast-cell like phenotype and tryptase was released in the serum-free medium. To correlate total serum tryptase (ts-try) levels with cytogenetic features and KIT mutational status, we analyzed serum samples from AML patients at diagnosis. In 70 out of 155 patients (45%) we detected elevated ts-try (>15 ng/mL… CONTINUE READING

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