Corpus ID: 19496801

Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.

@article{Yeates1992TotalPO,
  title={Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.},
  author={R. A. Yeates and M. Schmid},
  journal={Arzneimittel-Forschung},
  year={1992},
  volume={42 3},
  pages={
          297-302
        }
}
  • R. A. Yeates, M. Schmid
  • Published 1992
  • Chemistry, Medicine
  • Arzneimittel-Forschung
  • The nearly total inhibition of development of pharmacological tolerance to an organic nitrate is reported here for the first time. The development of in vitro tolerance in the rabbit aorta to isosorbide-5-mononitrate (CAS 87-33-2) was potently inhibited by five structurally unrelated antioxidants--diaminodurol, ascorbic acid, potassium sulphite, pyrogallol and quercetin. Diaminodurol, ascorbic acid and potassium sulphite decreased, but quercetin increased, the spasmolytic activity of isosorbide… CONTINUE READING
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