Total pathogenic allele frequency of autosomal recessive MEFV mutations causing familial Mediterranean fever in Tunisia and Morocco

  • Teeuw Me, Kelmemi, +8 authors Cornel Mc
  • Published 2015

Abstract

The total frequency of pathogenic alleles causing an autosomal recessive disorder can be estimated from mutational data on affected children of consanguineous parents and the inbreeding coefficient of the patients by means of a maximum likelihood method. In this chapter this method is applied to estimate the allele frequencies of bi-allelic autosomal… (More)

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Cite this paper

@inproceedings{Me2015TotalPA, title={Total pathogenic allele frequency of autosomal recessive MEFV mutations causing familial Mediterranean fever in Tunisia and Morocco}, author={Teeuw Me and Kelmemi and Jonker Ma and Kharrat M Lariani and Laarabi Fz and Hama I and Henneman L and Sefiani A and Chaabouni H and Kate Lp and Cornel Mc}, year={2015} }