Total parenteral nutrition directly impairs cytokine production after bacterial challenge.

@article{Okada1999TotalPN,
  title={Total parenteral nutrition directly impairs cytokine production after bacterial challenge.},
  author={Yasuhiro Okada and E. Sz. Papp and Nigel Klein and Agostino Pierro},
  journal={Journal of pediatric surgery},
  year={1999},
  volume={34 2},
  pages={277-80}
}
BACKGROUND/PURPOSE Previous studies have shown that total parenteral nutrition (TPN) influences host immunity, but the mechanism is unclear. This study explored the effect of TPN solution on neutrophil phagocytosis and whole-blood cytokine production in response to coagulase-negative staphylococci in vitro challenge. METHODS Blood samples were taken from five enterally fed infants (age <6 months) and six healthy adults. Samples were incubated for 45 minutes with four isovolemic solutions: (A… CONTINUE READING