Total marrow irradiation: a new ablative regimen as part of tandem autologous stem cell transplantation for patients with multiple myeloma.

@article{Somlo2011TotalMI,
  title={Total marrow irradiation: a new ablative regimen as part of tandem autologous stem cell transplantation for patients with multiple myeloma.},
  author={George Somlo and Ricardo T. Spielberger and Paul Frankel and Chatchada Karanes and Amrita R Krishnan and Pablo M. Parker and Leslie L Popplewell and Firoozeh Sahebi and Neil M Kogut and David Snyder and An Ying Liu and Timothy E. Schultheiss and Stephen J. Forman and Jeffrey Chun-Fai Wong},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 1},
  pages={
          174-82
        }
}
PURPOSE To establish feasibility, maximum tolerated dose (MTD), and potential efficacy of ablative dose total marrow irradiation (TMI) delivered by helical tomotherapy in patients with multiple myeloma (MM). EXPERIMENTAL DESIGN Patients with responding or stable MM received tandem autologous stem cell transplants, first with melphalan 200 mg/m(2), and 60 days or later with TMI. TMI doses were to be escalated from 1,000 cGy by increments of 200 cGy. All patients received thalidomide and… CONTINUE READING

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