Total lymphoid irradiation.

  title={Total lymphoid irradiation.},
  author={Simon M. Helfgott},
  journal={Rheumatic diseases clinics of North America},
  volume={15 3},
Total lymphoid irradiation (TLI) was shown to have potent immunosuppressive effects in patients with Hodgkin's disease. In the last decade a handful of studies assessed the efficacy of TLI in patients with rheumatoid arthritis. A correlation between decline in T-helper cell number and a reduction in disease activity was noted in all studies; however, the toxicity of TLI remains a major problems limiting a more widespread use of this treatment modality.