Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

@article{Herreman2000TotalIO,
  title={Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells},
  author={An Herreman and Lutgarde Serneels and Wim Annaert and D{\'e}sir{\'e} Collen and Luc Schoonjans and Bart de Strooper},
  journal={Nature Cell Biology},
  year={2000},
  volume={2},
  pages={461-462}
}
he question of how proteins such as the β-amyloid precursor protein (β-APP), Notch-1 and others can be cleaved in the plane of the membrane has challenged cell biologists and researchers into Alzheimer’s disease for some time. Processing of β-APP by γ-secretase is considered an important therapeutic target, as it constitutes the final step in the release of the amyloid βpeptide (Aβ), the principal constituent of the amyloid plaques in the brains of Alhzeimer’s patients. Recently, γ-secretase… CONTINUE READING
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