Total flavonoids of litsea coreana enhance the cytotoxicity of oxaliplatin by increasing gap junction intercellular communication.

@article{Yu2014TotalFO,
  title={Total flavonoids of litsea coreana enhance the cytotoxicity of oxaliplatin by increasing gap junction intercellular communication.},
  author={Bin-bin Yu and Shu-ying Dong and Mei-ling Yu and Guo-jun Jiang and J. Ji and X. Tong},
  journal={Biological \& pharmaceutical bulletin},
  year={2014},
  volume={37 8},
  pages={
          1315-22
        }
}
Oxaliplatin is widely used in the treatment of variety of cancers, including cancer of the testis and colorectum. Gap junctions (GJs) can amplify the cytotoxicity of antinoeoplastic drugs through the bystander effect in different cancer cells. In this study, we demonstrate that total flavonoids of litsea coreana (TFLC), one extract from the dried leaves of litsea coreana leve, increase the cytotoxicity of oxaliplatin in mouse testicular cancer I-10 cells. We found that cell survival was… Expand
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