Total fasting in the treatment of obesity.

  title={Total fasting in the treatment of obesity.},
  author={Ian C. Gilliland},
  journal={Postgraduate Medical Journal},
  pages={58 - 61}
  • I. Gilliland
  • Published 1 January 1968
  • Biology, Medicine
  • Postgraduate Medical Journal
DAUGHADAY, W.H., SALMON, W.D. & ALEXANDER, J. (1959) Sulfation factor activity of sera from patients with pituitary disorders. J. clin. Endocr. 19, 743. FRANTZ, A.G. & RABKIN, M.T. (1965) Effects of oestrogen and sex differences on secretion ofhuman growth hormone. J. clin. Endocr. 25, 1470. GELLER, J. & LOH, A. (1963) Identification and measurement of growth hormone in extracts of human urine. J. clin. Endocr. 23, 1107. GIRARD, J. & GREENWOOD, F.C. (1967) The radioimmunoassay of urine for… 

Standard procedures for assessing hypersecretion or secretory capacity for human growth hormone, using the radioimmunoassay.

Appropriate diagnostic procedures for assessing GH activity in relation to various clinical problems have now evolved and here the authors shall appraise the use of some of these procedures, and define the normal responses.

Ketogenic diets as treatment of obesity and type 2 diabetes mellitus

VLCKDs should be considered as an excellent initial step in properly selected and motivated patients with obesity or type 2 diabetes, to be delivered as a part of a multicomponent strategy and under strict medical supervision.

Uric acid metabolism in starvation.

Two groups of subjects were obese and were admitted to hospital for therapeutic starvation, and one group was given allopurinol in a dose of 200 mg.

Dietary Treatment of Obesity

Success of any diet therapy depends on many factors other than the diet itself, which is often a minor consideration, so one can speculate on the maximum amount of weight loss which can be achieved 1.

Epigenome Modulation Induced by Ketogenic Diets

This review provides an overview of the major epigenetic changes associated with Ketogenic diets as well as investigating the intracellular metabolic pathways that contribute to the beneficial effects of these diets.

Long-term efficacy of medical treatments for obesity

  • O. Linet
  • Medicine
    Klinische Wochenschrift
  • 2005
Fasting and protein sparing modified fast are indicated for patients with a high degree of obesity, i.e. for those who are at least 30% or 25 kg or more over their ideal body weight, and both these procedures have definite risks.

Fasting as a Therapy in Neurological Disease

Fasting improves cognition, stalls age-related cognitive decline, usually slows neurodegeneration, reduces brain damage and enhances functional recovery after stroke, and mitigates the pathological and clinical features of epilepsy and multiple sclerosis in animal models.

Total fasting, hyperuricaemia and gout

Hyperuricaemia occurred in forty-two obese subjects treated by total fasting. This was apparently harmless in that it did not lead to acute gout in any patient, including one male known to be a

The role of positive psychology in the treatment of overweight and obesity, and its effects on molecular genetic pathways involved

The PPI may be able to modulate expression of genes related to positive psychological functioning, leading to increased well-being, and it is proposed that the OXTR expression levels could be used as an experimental assay in validation of PPIs, promoting the practical legacy of PP.

A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis

A mathematical model of weight loss under total starvation using the established principles of energy balance found that fatter individuals would indeed survive longer and, at a given body weight, females would survive longer than males, when totally starved.



Occurrence of acute Wernicke's encephalopathy during prolonged starvation for the treatment of obesity.

The more liberal use of prolonged starvation in the treatment of obesity has posed a number of questions regarding the metabolic requirements of body tissues under these conditions, and it has been noted that thiamine requirements fall with diminishing physical activity.


Prolonged starvation is not advised for obese patients with a history of ischemic cardiovascular or cerebral disease, with history of gout, or with hepatic diseahypo.

Measurement of Serum Uric Acid in Great Britain in 1963

The measurement of serum uric acid plays as important a role in studies on gout as does that of glucose in diabetes mellitus; yet in practice the results often conflict with clinical impressions or have been found to lead to a wrong diagnosis.



The case of an extremely obese diabetic patient who acquired lactic acidosis while fasting and who subsequently died is described, and to the knowledge, until the present time there have been no reports of death in association with therapeutic starvation.

The results of treatment for obesity: a review of the literature and report of a series.

This report documents the ineffectiveness of weight-reduction programs, as reported in the medical literature of the past 30 years, and the results of routine treatment of 100 consecutive obese persons in the Nutrition Clinic of the New York Hospital.

Treatment of obesity by total fasting for up to 249 days.