Total cholesterol and risk of mortality in the oldest old

@article{WeverlingRijnsburger1997TotalCA,
  title={Total cholesterol and risk of mortality in the oldest old},
  author={Annelies W E Weverling-Rijnsburger and Gerard Jan Blauw and A. Margot Lagaay and Dick L Knock and Arend E. Meinders and Rudi G. J. Westendorp},
  journal={The Lancet},
  year={1997},
  volume={350},
  pages={1119-1123}
}
BACKGROUND The impact of total serum cholesterol as a risk factor for cardiovascular disease decreases with age, which casts doubt on the necessity for cholesterol-lowering therapy in the elderly. [...] Key Method Three categories of total cholesterol concentrations were defined: < 5.0 mmol/L, 5.0-6.4 mmol/L, and > or = 6.5 mmol/L. In a subgroup of 137 participants, total cholesterol was measured again after 5 years of follow-up.Expand
Serum total cholesterol and risk of cardiovascular and non-cardiovascular mortality in old age: a population-based study
TLDR
The inverse association between high total cholesterol and reduced all-cause mortality in older adults is primarily due to non-cardiovascular mortality, especially among those who are not treated with cholesterol-lowering medications. Expand
Low total cholesterol predicts mortality in the nondemented oldest old.
TLDR
Levels of total cholesterol lower than those of young subjects are found, but when the total cholesterol decreases below a hypothetical critical limit of 160 mg/dl represent, an important index of frailty in the oldest old and a predictor of mortality. Expand
High-density vs low-density lipoprotein cholesterol as the risk factor for coronary artery disease and stroke in old age.
TLDR
In contrast to high LDL cholesterol level, low HDL cholesterol level is a risk factor for mortality from coronary artery disease and stroke in old age, and is unaffected by comorbidity. Expand
Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men.
TLDR
Differences in lipid levels that are achievable by statin use were associated with about a one-third lower risk of IHD in older men, irrespective of age. Expand
Serum total cholesterol concentration and 10-year mortality in an 85-year-old population
TLDR
Results indicate an association between lower serum TC concentrations and increased all-cause mortality in a community-dwelling, very elderly population and suggest that low TC and low LDL-C may be independent predictors of high mortality in the very elderly. Expand
Serum lipids and their association with mortality in the elderly: a prospective cohort study
TLDR
High levels of serum total cholesterol and particularly low levels of HDL-c seem to be risk factors for cardiovascular mortality even in the elderly population. Expand
Trajectory of Total Cholesterol in the Last Years of Life Over Age 80 Years: Cohort Study of 99,758 Participants
TLDR
TC values show a terminal decline in the last years of life, and reverse causation may contribute to the association of lower TC with higher mortality in nonrandomized studies. Expand
Dynamics of traditional metabolic risk factors associate with specific causes of death in old age.
BACKGROUND In contrast to middle age, higher body mass index (BMI), cholesterol levels, and blood pressures associate no longer with increased mortality in old age. With increasing age, these riskExpand
Serum total cholesterol: a mortality predictor in elderly hospitalized patients.
TLDR
In very elderly hospitalized subjects, increased levels of serum total cholesterol and albumin may be associated with reduced mortality risk in the hospitalized elderly. Expand
Hypercholesterolaemia and risk of coronary heart disease in the elderly: impact of age: the Copenhagen City Heart Study.
TLDR
The risk of incident CHD associated with high plasma-cholesterol declines with age, and this finding should be considered in future recommendations of plasma-Cholesterol levels in elderly people without atherosclerotic cardiovascular disease. Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Cholesterol and mortality. 30 years of follow-up from the Framingham study.
TLDR
Under age 50 years these data suggest that having a very low cholesterol level improves longevity, and after age50 years the association of mortality with cholesterol values is confounded by people whose cholesterol levels are falling--perhaps due to diseases predisposing to death. Expand
Decline in Serum Total Cholesterol and the Risk of Death from Cancer
TLDR
The group with the highest decline in cholesterol displayed an excess risk for most cancer sites, and these associations were more pronounced in subjects whose weight remained stable or decreased over time than in those who gained weight. Expand
Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years.
TLDR
The hypothesis that hypercholesterolemia or low HDL-C are important risk factors for all-cause mortality, coronary heart disease mortality, or hospitalization for myocardial infarction or unstable angina in this cohort of persons older than 70 years is not supported. Expand
Inverse association between serum total cholesterol and cancer mortality in Dutch civil servants.
TLDR
Low serum cholesterol seems not to be attributable to undetected cancer, but might be a risk factor for cancer mortality in men, according to a 28-year follow-up study of Dutch civil servants. Expand
Clarifying the Direct Relation between Total Cholesterol Levels and Death from Coronary Heart Disease in Older Persons
TLDR
The association between total cholesterol level and death from coronary heart disease is reported on using prospective data from the EPESE study, a community-based cohort study of men and women 71 years of age and older. Expand
Serum cholesterol and 25-year incidence of and mortality from myocardial infarction and cancer. The Zutphen Study.
TLDR
Survival analysis showed that the serum cholesterol level in 1960 was independently related to the 25-year incidence of myocardial infarction, and similar but less pronounced relations were found between serum cholesterollevel and 15- and 25- year mortality from myocardia infarctions. Expand
Time Trends in Serum Cholesterol before Cancer Death
TLDR
It is suggested that these time trends can plausibly be attributed to the effects of prevalent cancer on lowering serum cholesterol and add weight to the argument that the low cholesterol‐cancer mortality relation does not arise because of any causal contribution of low serum total cholesterol to the risk of cancer. Expand
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators.
TLDR
It is demonstrated that the benefit of cholesterol-lowering therapy extends to the majority of patients with coronary disease who have average cholesterol levels and was also greater in patients with higher pretreatment levels of LDL cholesterol. Expand
Cholesterol, diastolic blood pressure, and stroke: 13 000 strokes in 450 000 people in 45 prospective cohorts
TLDR
The associations of blood cholesterol and diastolic blood pressure with subsequent stroke rates were investigated by review of 45 prospective observational cohorts involving 450,000 individuals with 5-30 years of follow-up, finding that the effects of therapeutic blood pressure reductions should be assessed separately in middle age and in old age. Expand
Serum cholesterol and mortality among Japanese-American men. The Honolulu (Hawaii) Heart Program.
TLDR
It is suggested that the nutritional demands of cancers may not entirely explain the inverse association with some cancers, and the inverse relationship between cancer and serum cholesterol levels was stronger in the first 6 years than in the next 6 years and, although still inverse, lost statistical significance after 13 years. Expand
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