Total chemical synthesis of proteins.

@article{Kent2009TotalCS,
  title={Total chemical synthesis of proteins.},
  author={Stephen B. H. Kent},
  journal={Chemical Society reviews},
  year={2009},
  volume={38 2},
  pages={338-51}
}
This tutorial review outlines the modern ligation methods that enable the efficient total chemical synthesis of enzymes and other protein molecules. Key to this success is the chemoselective reaction of unprotected synthetic peptides ('chemical ligation'). Notably, native chemical ligation enables the reaction of two unprotected peptides in aqueous solution at neutral pH to form a single product in near quantitative yield. Full-length synthetic polypeptides are folded to form the defined… CONTINUE READING

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