Total chemical synthesis of proteins.

@article{Kent2009TotalCS,
  title={Total chemical synthesis of proteins.},
  author={Stephen B. H. Kent},
  journal={Chemical Society reviews},
  year={2009},
  volume={38 2},
  pages={
          338-51
        }
}
  • S. Kent
  • Published 26 January 2009
  • Chemistry, Biology
  • Chemical Society reviews
This tutorial review outlines the modern ligation methods that enable the efficient total chemical synthesis of enzymes and other protein molecules. Key to this success is the chemoselective reaction of unprotected synthetic peptides ('chemical ligation'). Notably, native chemical ligation enables the reaction of two unprotected peptides in aqueous solution at neutral pH to form a single product in near quantitative yield. Full-length synthetic polypeptides are folded to form the defined… 

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  • S. Kent
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  • 2017

Recent extensions to native chemical ligation for the chemical synthesis of peptides and proteins.

Sequential native peptide ligation strategies for total chemical protein synthesis.

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Modern extensions of native chemical ligation for chemical protein synthesis.

This chapter details a number of important extensions of the original native chemical ligation manifold, with particular focus on the application of new methods in the total chemical synthesis of proteins.
...

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