Total and free plasma tryptophan levels in patients with affective disorders: effects of a peripheral decarboxylase inhibitor.

@article{Garfinkel1976TotalAF,
  title={Total and free plasma tryptophan levels in patients with affective disorders: effects of a peripheral decarboxylase inhibitor.},
  author={Paul E. Garfinkel and Jerry J. Warsh and Harvey C. Stancer and David Sibony},
  journal={Archives of general psychiatry},
  year={1976},
  volume={33 12},
  pages={
          1462-6
        }
}
Previous reports of decreased cerebrospinal fluid tryptophan levels and decreased free plasma tryptophan levels, as well as a reduction in the volume of distribution of tryptophan, suggest that alterations in the disposition of plasma tryptophan may occur in depressives. We examined the disposition of plasma tryptophan in ten normal controls and ten depressed patients. These measures were made on two drug-free baseline days and on two days when the subjects had been receiving the peripheral… 

Tryptophan and depressive illness

Although exogenously administered oestrogens do not have any therapeutic efficacy in relieving mild residual depressive symptoms of lithium treated patients, they increased the levels of plasma free tryptophan, which reduced the levels in depressed patients.

Kinetics of l-tryptophan in depressive patients: A possible correlation between the plasma concentrations of l-tryptophan and some psychiatric rating scales

No kinetic differences could be demonstrated in the depressive patients, making differences in body compartments or flux of l-tryptophan unlikely to be of pathogenic importance to depression.

Plasma tryptophan binding to albumin in unipolar depressives

No differences in the equilibrium constants were detected between patients and controls but a small increase in the albumin concentration was noted in the depressives and it was agreed that this rise would be inadequate to lead to a significant effect on free tryptophan levels.

Blood tryptophan metabolism in chronic schizophrenics.

Concomitant measures of blood indole metabolism were conducted in 33 chronic schizophrenics who showed significantly elevated mean platelet serotonin (5-HT) values and lower platelet monoamine

L-Tryptophan in Psychiatric Practice

The greatest utility of L-tryptophan is probably as a concomitant agent withMAO inhibitors, and in depressions that have not responded to tricyclic antidepressants, MAO inhibitors alone, or electroconvulsive therapy.

Diurnal rhythm in the plasma level of total and free tryptophan and cortisol in rabbits

  • L. HusseinH. Goedde
  • Biology
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
  • 1979
The results suggest that tryptophan in plasma is poorly transported in the brains of rabbits treated with chlorpromazine, and that treatment with haloperidol or chlor Promazine may lead to a reduced tryptophile flux into the kynurenine pathway.

Tryptophan, Cortisol and Puerperal Mood

Seasonal variation occurred in the incidence of 'blues' and in cortisol and free tryptophan levels, and Puerperally-depressed mood was correlated with high cortisol at 38 weeks irrespective of season.

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