Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats.

@article{Bauss2002TotalAD,
  title={Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats.},
  author={Frieder Bauss and Martina Wagner and Ludwig H Hothorn},
  journal={The Journal of rheumatology},
  year={2002},
  volume={29 5},
  pages={
          990-8
        }
}
OBJECTIVE Ibandronate is a highly potent nitrogen-containing bisphosphonate that can prevent bone loss in various animal models as well as in clinical trials. We evaluated the effects of different doses and treatment schedules in ovariectomized aged rats, a model of human osteoporosis. METHODS Eight-month-old female Wistar rats were ovariectomized or sham operated (n = 15/group). Doses of 0.1 to 30 microg/kg/day ibandronate were administered subcutaneously over a period of 20 weeks with or… CONTINUE READING

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