Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

@article{WiktorJedrzejczak1990TotalAO,
  title={Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.},
  author={Wieslaw Wiktor-Jedrzejczak and Anna Bartocci and Anthony W. Ferrante and Aftab Ahmed-Ansari and Kenneth W. Sell and Jeffrey W Pollard and E Richard Stanley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 12},
  pages={4828-32}
}
Osteopetrotic (op/op) mutant mice suffer from congenital osteopetrosis due to a severe deficiency of osteoclasts. Furthermore, the total number of mononuclear phagocytes is extremely low in affected mice. Serum, 11 tissues, and different cell and organ conditioned media from op/op mice were shown to be devoid of biologically active colony-stimulating factor 1 (CSF-1), whereas all of these preparations from littermate control +/+ and +/op mice contained the growth factor. The deficiency was… CONTINUE READING

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