Total Synthesis of a Dimeric Thymol Derivative Isolated from Arnica sachalinensis.

@article{Silvestro2017TotalSO,
  title={Total Synthesis of a Dimeric Thymol Derivative Isolated from Arnica sachalinensis.},
  author={Irene De Silvestro and Samuel L Drew and Gary S Nichol and Fernanda Duarte and Andrew L Lawrence},
  journal={Angewandte Chemie},
  year={2017},
  volume={56 24},
  pages={6813-6817}
}
The total synthesis of a dimeric thymol derivative (thymarnicol) isolated from Arnica sachalinensis was accomplished in 6 steps. A key biomimetic Diels-Alder dimerization was found to occur at ambient temperature and the final oxidative cyclization occurs when the substrate is exposed to air and visible light. These results indicate that this natural… CONTINUE READING