Total Synthesis of Sinensilactam A.

  title={Total Synthesis of Sinensilactam A.},
  author={Wenbing Shao and Jun Huang and Kai Guo and Jianxian Gong and Zhen Yang},
  journal={Organic letters},
  volume={20 7},
The total synthesis of naturally occurring (±)-sinensilactam A was achieved in 18 steps. The key steps of this work are a rhodium-catalyzed [3 + 2] cycloaddition for construction of the two all-carbon vicinal quaternary centers and a convergent and tandem condensation of the in situ generated N-acyliminium intermediate with aldehyde 20. This enabled implementation of a unified strategy for stereoselective formation of the tetracyclic hemiaminal core of sinensilactam A in a later stage. The… 
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