Total Synthesis of Neuroprotective Dictyoquinazol A, B, and C

@article{Oh2007TotalSO,
  title={Total Synthesis of Neuroprotective Dictyoquinazol A, B, and C},
  author={Chang Ho Oh and Chung Hyun Song},
  journal={Synthetic Communications},
  year={2007},
  volume={37},
  pages={3311 - 3317}
}
  • C. Oh, C. Song
  • Published 1 September 2007
  • Chemistry
  • Synthetic Communications
Abstract A new protective compound, dictyoquinazol A, was synthesized starting from 5‐methoxy‐2‐nitrobenzoic acid in six‐steps in 36% overall yield. Two derivatives B and C, isolated from the mushroom Dictyophora indusiata, were also synthesized from Dictyoquinazole A. 
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References

SHOWING 1-8 OF 8 REFERENCES
Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata.
TLDR
Dictyoquinazols protected primary cultured mouse cortical neurons from glutamate- and NMDA-induced excitotoxicities in a dose-dependent manner.
Neuroprotective bibenzyl glycosides of Stemona tuberosa roots.
TLDR
Three new bibenzyl glycosides characterized as stilbostemin B, H, and I significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
Quinazolin-4-one alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists: structure-activity relationship of the C-2 side chain tether.
TLDR
New AMPA receptor antagonists, containing the methylamino tether group, have been identified from this effort, and the relative potencies of the new compounds ranged from 11 nM to greater than 10 microM.
The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
TLDR
Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site, which contributes to delayed tissue damage after brain trauma.
The role of glutamate in neurotransmission and in neurologic disease.
TLDR
Pharmacologic manipulation of the glutamatergic system may have great potential for the rational treatment of a variety of neurologic diseases.
AMPA receptor agonists, antagonists and modulators: their potential for clinical utility
TLDR
From the understanding of neuronal circuitry and its involvement in brain function, agonists and positive allosteric modulators are predicted to improve the negative symptomatology in schizophrenia, and to improve memory, behavioural and cognition skills in dementias associated with neurodegenerative disorders or trauma.