Total Synthesis of Natural Products: At the Frontiers of Organic Chemistry

  title={Total Synthesis of Natural Products: At the Frontiers of Organic Chemistry},
  author={Jie Jack Li and E. J. Corey},
  journal={Total Synthesis of Natural Products},
  • J. Li, E. Corey
  • Published 2012
  • Chemistry
  • Total Synthesis of Natural Products
Nominine.- Nakiterpiosin: A Novel C-nor-D-homosteroid.- The Kinamycins.- A Short Synthesis of Strychinine from Pyridine.- Bryostatin 7.- Serratezomine A.- Hypocrellin/Cercosporin.- Total Synthesis of Phomactin A.- (+)-11,11'-Dideoxyverticillin A.- Retigeranic Acid.- Companadine A. 
8 Citations
Ruthenium(ii)-catalyzed C–O/C–S cyclization for the synthesis of 5-membered O-containing and S-containing heterocycles
An efficient and convenient method for the synthesis of oxazole derivatives from enamides has been established via a ruthenium-catalyzed C–O cyclization.
An atom efficient synthesis of tamoxifen.
By employing the recently discovered highly active palladium nanoparticle based catalyst, an alkenyllithium reagent with a high (Z/E) selectivity and good yield is couple to give the breast cancer drug tamoxifen in just 2 steps from commercially available starting materials and with excellent atom economy and reaction mass efficiency.
Stereoselective syntheses of substituted tert-butyl 3-allyl-4-hydroxypiperidine-1-carboxylate
Abstracttert-Butyl 3-allyl-4-oxopiperidine-1-carboxylate and its derivatives substituted at the 3-position and in the allylic fragment reacted with L-selectride in anhydrous tetrahydrofuran to give
Plants as Sources of Anti-Inflammatory Agents
Highlights from the published literature on plants as sources of anti-inflammatory agents are presented, including highlights from a limited regional perspective.
Desktop NMR for structure elucidation and identification of strychnine adulteration.
This paper demonstrates the use of low-field NMR spectroscopy in chemical forensics for identifying strychnine and its counterions by exploring the chemical shift as a signature in different 1D 1H and 13C experiments.
Taking electrodecarboxylative etherification beyond Hofer–Moest using a radical C–O coupling strategy
The electrodecarboxylative radical-radical coupling of lithium alkylcarboxylates with 1-hydroxybenzotriazole at platinum electrodes in methanol/pyridine to affordAlkyl benzotrizole ethers is reported, which demonstrates that electrodecarbonised C–O bond formation can be taken beyond the intrinsic substrate limitations of Hofer-Moest mechanisms.
Natural product drug discovery in the artificial intelligence era
Rational applications of AI approaches developed to assist in discovering bioactive NPs and capturing the molecular “patterns” of these privileged structures for combinatorial design or target selectivity are reviewed.
Dissociative Adsorption of Diethyl Ether on Si(001) Studied by Means of Scanning Tunneling Microscopy and Photoelectron Spectroscopy
The adsorption of diethyl ether (Et2O) on Si(001) was studied by means of scanning tunneling microscopy (STM) and photoelectron spectroscopy. Et2O reacts on Si(001) via a datively bonded


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