Corpus ID: 99268982

Total Synthesis of Lagunamide A via Remote Vinylogous Mukaiyama Aldol Reactions, Chemical Studies Toward the Total Synthesis of Micromide and Preliminary Studies Toward the Total Synthesis of Azaspirene

@inproceedings{Banasik2016TotalSO,
  title={Total Synthesis of Lagunamide A via Remote Vinylogous Mukaiyama Aldol Reactions, Chemical Studies Toward the Total Synthesis of Micromide and Preliminary Studies Toward the Total Synthesis of Azaspirene},
  author={Brent A. Banasik},
  year={2016}
}
Author(s): Banasik, Brent | Advisor(s): Bergdahl, Mikael; Molinski, Tadeusz | Abstract: Lagunamide A represents a class of novel cyclic depsipeptide obtained from the marine cyanobacterium Lyngbya majuscula. With an array of biological activity and impressive IC50 values including anti-malarial properties (IC50 0.19-0.91 μM), significant cytotoxic properties against P388 murine leukemia cell lines (IC50 6.4-20.5 nM) and ileocecal colon cancer (1.6 nM), lagunamide A shows promise as an extremely… Expand

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