Total Synthesis of Chaetoglobin A via Catalytic, Atroposelective Oxidative Phenol Coupling.
@article{Kang2018TotalSO,
title={Total Synthesis of Chaetoglobin A via Catalytic, Atroposelective Oxidative Phenol Coupling.},
author={Houng Kang and Carilyn Torruellas and Jinchu Liu and Marisa C. Kozlowski},
journal={Organic letters},
year={2018},
volume={20 18},
pages={
5554-5558
}
}The first total synthesis of chaetoglobin A (1), which features a chiral axis between two identical highly oxygenated bicyclic cores, was successfully completed in 12 steps from 2,6-dimethoxytoluene. Vanadium-catalyzed oxidative phenol coupling, as a key step, enabled generation of the axial chirality.
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