Total Synthesis of (-)-Lamellodysidine A via an Intramolecular Diels-Alder Reaction.

@article{Kamo2022TotalSO,
  title={Total Synthesis of (-)-Lamellodysidine A via an Intramolecular Diels-Alder Reaction.},
  author={Shogo Kamo and Hitomi Kurosawa and Akinobu Matsuzawa and Kazuyuki Sugita},
  journal={Organic letters},
  year={2022}
}
In this study, we achieved an eight-step enantioselective synthesis of (-)-lamellodysidine A, a structurally intriguing sesquiterpene natural product featuring a 5/5/6/6-fused tetracyclic skeleton that was obtained from the marine sponge Lamellodysidea herbacea. The key to the synthesis is a cascade reaction that includes an intramolecular Diels-Alder reaction. In addition, single-crystal X-ray crystallographic analysis of the synthetic (-)-lamellodysidine A clearly confirmed the proposed… 
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Total Synthesis of (–)-Lamellodysidine A
  • Chemistry
    Synfacts
  • 2022

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