Total Synthesis of (−)-Enigmazole A

  title={Total Synthesis of (−)-Enigmazole A},
  author={Yanran Ai and Mariya V. Kozytska and Yike Zou and Anton S. Khartulyari and Amos B. Smith},
  journal={Journal of the American Chemical Society},
  pages={15426 - 15429}
A highly convergent, stereocontrolled total synthesis of the architecturally complex marine sponge metabolite (−)-enigmazole A has been achieved. Highlights include an unprecedented late-stage large-fragment Petasis–Ferrier union/rearrangement, a multicomponent Type I Anion Relay Chemistry (ARC) tactic, and a dithiane–epoxide union in conjunction with an oxazole-directed stereoselective reduction. 
24 Citations
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