Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A
@article{Qi2014TotalSA, title={Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A}, author={Chao Qi and Tian Qin and Daisuke Suzuki and John A. Porco}, journal={Journal of the American Chemical Society}, year={2014}, volume={136}, pages={3374 - 3377} }
A concise, biomimetic approach to sorbiterrin A has been developed employing consecutive Michael additions of a 4-hydroxypyrone to a sorbicillinol derivative and silver nanoparticle-mediated bridged aldol/dehydration to construct the [3.3.1] ring system. The relative stereochemistry of sorbiterrin A was unambiguously confirmed by X-ray crystallographic analysis.
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