Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo‐ H) Antigen

  title={Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo‐ H) Antigen},
  author={Tae Kyo Park and I. J. Kim and Shuanghua Hu and Mark T Bilodeau and John T. Randolph and Ohyun Kwon and Samuel J Danishefsky},
Recent Development in Carbohydrate Based Anticancer Vaccines
The development of carbohydrate-based anticancer vaccines is of high current interest and the various strategies that have been developed to enhance the immunogenicity of these antigens are reviewed.
Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present.
Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience
The progression of the longstanding carbohydrate-based anticancer vaccine program is described, which is now at the threshold of clinical evaluation in several contexts, and a recently developed unimolecular multi-antigenic constructs and potential dual-acting constructs, which contain clusters of both carbohydrate and peptide epitopes are described.
Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines
This work has shown that the use of both state-of-the-art and emerging glycosylation technologies has led to significant advances in this field, allowing the clinical exploration of carbohydrate-based antigens in the treatment of cancer.
Preparation of Building Blocks for Carba‐Oligosaccharides: Some Protected 5a′‐Carba‐D‐hexopyranosyl‐1,5‐anhydro‐2‐deoxy‐D‐arabino‐hex‐1‐enitols, and 5a,5a′‐Dicarba Congeners Thereof
Four configurational types of two protected O‐linked (5a‐carba‐D‐hexopyranosyl)‐D‐glucal and carba‐D‐glucal derivatives were prepared in order to provide versatile synthetic intermediates readily
Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities
The authors present a historic account of their ongoing research program devoted to the development of fully synthetic, carbohydrate-based anticancer vaccines of clinical value, and describe the evolution of their synthetic carbohydrate program from first-generation constructs to highly complex unimolecular multivalent vaccines.
Automated synthesis of oligosaccharides as a basis for drug discovery
Particular focus will be placed on the development of carbohydrate-based vaccines, defined heparin oligosaccharides and aminoglycosides that have recently begun to affect drug discovery.
Vaccination of Patients with Small-Cell Lung Cancer with Synthetic Fucosyl GM-1 Conjugated to Keyhole Limpet Hemocyanin
Testing the immunogenicity of three different doses of a synthetic version of fucosyl-GM1 in patients with SCLC after a major response to initial therapy found an IgM antibody response comparable with the response induced by the bovine derivative.
Synthesis of Novel 7α-Thiol-Bridged Progesterone Derivatives
This multi-step synthesis proceeds via the dehydrogenation of the endocyclic ketone moiety of the steroid, affording the resulting α,β–γ,δ-unsaturated system.


Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo-H) Antigen
The total synthesis of the Hakomori MBr1 antigen, heavily expressed on human breast tumors, is related. The construction involved the assembly of four glycals:  (17 (twice), 18, 20, and 26) and an