Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.

@article{Handore2015TotalSA,
  title={Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.},
  author={Kishor L Handore and Prakash D Jadhav and Bibhabasu Hazra and Anirban Basu and D Srinivasa Reddy},
  journal={ACS medicinal chemistry letters},
  year={2015},
  volume={6 11},
  pages={1117-21}
}
The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential… CONTINUE READING