Total RNA yield and microarray gene expression profiles from fine-needle aspiration biopsy and core-needle biopsy samples of breast carcinoma.

@article{Symmans2003TotalRY,
  title={Total RNA yield and microarray gene expression profiles from fine-needle aspiration biopsy and core-needle biopsy samples of breast carcinoma.},
  author={W. Fraser Symmans and Mark Ayers and Edwin A. Clark and James P. Stec and Kenneth R. Hess and Nour Sneige and Thomas A. Buchholz and Savitri Krishnamurthy and Nuhad K. Ibrahim and Aman U. Buzdar and Rachel Leigh Theriault and Marguerite F M Rosales and Eva S. Thomas and Karin M. Gwyn and Marjorie C. Green and Abdul R Syed and Gabriel N Hortobagyi and Lajos Pusztai},
  journal={Cancer},
  year={2003},
  volume={97 12},
  pages={2960-71}
}
BACKGROUND Gene expression profiling should be applicable to needle biopsy samples if microarray technology is to become practically useful for clinical research or management of breast carcinoma. This study compared gene expression profiles derived from fine-needle aspiration biopsy (FNAB) and from core needle biopsy (CBX). METHODS Total RNA was extracted from single FNAB and CBX samples. Corresponding pairs of FNAB and CBX were analyzed for similarity of gene expression profiles using cDNA… CONTINUE READING