Total Energy Production and Phosphocreatine Hydrolysis in the Isotonic Twitch

  title={Total Energy Production and Phosphocreatine Hydrolysis in the Isotonic Twitch},
  author={Francis D. Carlson and Donna J. Hardy and Douglas R. Wilkie},
  journal={The Journal of General Physiology},
  pages={851 - 882}
Using frog's sartorius muscles we have found no correlation between phosphocreatine hydrolysis and shortening under conditions (iodoacetate poisoning and anoxia) where this reaction was the only expected source of energy. Phosphocreatine hydrolysis did, however, show a constant term corresponding to the activation heat of A.V. Hill, and a linear term with work. It was concluded that shortening heat comes from some other chemical reaction, or else Hill's equation (E = A + W + ax) fails to… CONTINUE READING


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1 Excerpt

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