Torsion-Mediated Interaction between Adjacent Genes

@inproceedings{Meyer2014TorsionMediatedIB,
  title={Torsion-Mediated Interaction between Adjacent Genes},
  author={Sam Meyer and Guillaume Beslon},
  booktitle={PLoS Computational Biology},
  year={2014}
}
DNA torsional stress is generated by virtually all biomolecular processes involving the double helix, in particular transcription where a significant level of stress propagates over several kilobases. If another promoter is located in this range, this stress may strongly modify its opening properties, and hence facilitate or hinder its transcription. This mechanism implies that transcribed genes distant of a few kilobases are not independent, but coupled by torsional stress, an effect for which… CONTINUE READING
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