Torsemide inhibits aldosterone secretion in vitro.

@article{Goodfriend1998TorsemideIA,
  title={Torsemide inhibits aldosterone secretion in vitro.},
  author={T. Goodfriend and D. Ball and W. Oelkers and V. B{\"a}hr},
  journal={Life sciences},
  year={1998},
  volume={63 3},
  pages={
          PL45-50
        }
}
Torsemide inhibited aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. Inhibitory concentrations for adrenal cells (micromolar) were comparable with those reported to inhibit ion transport in isolated renal tubules. Inhibition of aldosterone secretion could reduce kaliuresis, and that may explain why torsemide causes less kaliuresis than other diuretics. 
44 Citations
The Diuretic Torasemide Does Not Prevent Aldosterone-Mediated Mineralocorticoid Receptor Activation in Cardiomyocytes
  • 31
  • PDF
Comparative effects of torasemide and furosemide in rats with heart failure.
  • 41
Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.
  • 20
  • PDF
Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy.
  • 28
  • Highly Influenced
[Effects of various diuretics on cardiac function in rats with heart failure].
  • 8
Genetic polymorphisms in genes regulating renal ion excretion and diuretic drug effects
A reappraisal of loop diuretic choice in heart failure patients.
  • 49
Sodium and Fluid Excretion With Torsemide in Healthy Subjects is Limited by the Short Duration of Diuretic Action
  • 8
  • PDF
Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis
  • 7
  • PDF
...
1
2
3
4
5
...