Torpedo Formation and Purkinje Cell Loss: Modeling their Relationship in Cerebellar Disease

@article{Louis2014TorpedoFA,
  title={Torpedo Formation and Purkinje Cell Loss: Modeling their Relationship in Cerebellar Disease},
  author={Elan Daniel Louis and S T Kuo and Jean Paul G. Vonsattel and Phyllis L. Faust},
  journal={The Cerebellum},
  year={2014},
  volume={13},
  pages={433-439}
}
Torpedo formation and Purkinje cell (PC) loss represent standard and inter-related cerebellar responses to injury. Surprisingly, the nature of their relationship has not been carefully characterized across a range of normal and disease states. Are brains with more torpedoes expected to have fewer PCs? We quantified torpedoes and PCs in four groups: essential tremor (ET), spinocerebellar ataxia (SCA), multiple system atrophy-cerebellar (MSA-C), and controls. Brains from 100 individuals (58 ET… CONTINUE READING
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Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias

Tremor and other hyperkinetic movements • 2017

Essential Tremor: A Common Disorder of Purkinje Neurons?

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry • 2016

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