Tormentillae rhizoma - Review for an Underestimated European Herbal Drug.

@article{Melzig2020TormentillaeR,
  title={Tormentillae rhizoma - Review for an Underestimated European Herbal Drug.},
  author={M. Melzig and S. B{\"o}ttger},
  journal={Planta medica},
  year={2020}
}
Potentilla erecta is a medicinal plant described under its traditional name Tormentil in medieval herbal books and used until today in many European countries. Today monographs for Tormentillae rhizoma in the European pharmacopeia, as well as a monograph of the Herbal Medicinal Product Commission as a drug for traditional use, exist. The present review summarizes published investigations in phytochemistry and pharmacology, together with new findings reflecting the mechanisms of action of… Expand
Recent phytochemical and pharmacological advances in the genus Potentilla L. sensu lato - An update covering the period from 2009 to 2020.
TLDR
In vitro studies must be re-considered due to the discovery of urolithins and their origins, including microbiota, which can lead to different results when applying Potentilla species and their extracts to in vivo conditions, so future research should focus more on in vivo studies to confirm the validity and safety of traditional uses. Expand
COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
TLDR
Several herbal medicines traditionally indicated for “respiratory diseases” have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical discussion about their potential use as adjuvants in the treatment of early/mild common flu in otherwise healthy adults within the context of COVID-19. Expand
Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes
TLDR
The present results show that TE may exert multidirectional effects on hemostasis in STZ-induced diabetic rats and mice, and showed unfavorable effects by increasing the activity of the coagulation system and by inhibiting fibrinolysis. Expand

References

SHOWING 1-10 OF 59 REFERENCES
Potentilla--a review of its phytochemical and pharmacological profile.
TLDR
This comprehensive review provides a botanical description of Potentilla species and their phytochemical constituents in the aerial and underground parts and recommends that future efforts should concentrate more on in vitro and in vivo studies and also on clinical trials in order to confirm traditional wisdom in the light of a rational phytotherapy. Expand
Anti-inflammatory and vasoconstrictive properties of Potentilla erecta - A traditional medicinal plant from the northern hemisphere.
TLDR
PE displays anti-inflammatory and vasoconstrictive effects and might therefore be beneficial for the topical treatment of inflammatory skin disorders. Expand
Determination of acute toxicity of the aqueous extract of Potentilla erecta (Tormentil) rhizomes in rats and mice.
TLDR
P. erecta rhizome extracts should be considered safe with respect to acute toxicity when applied to humans with results from recent clinical trials in which no signs of any toxic effects have been known after the administration of a P. erecto-rhizome extract. Expand
A comprehensive review of agrimoniin
TLDR
Agrimoniin is a constituent of medicinal plants, which are often applied orally in the form of infusions, decoctions, or tinctures, and is metabolized by human gut microbiota into a series of low‐molecular‐weight urolithins with proven anti‐inflammatory and anticancer in vivo and in vitro bioactivities. Expand
Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies
TLDR
Herbal therapies exert their therapeutic benefit via various mechanisms, including immune regulation, anti-oxidant activity, inhibition of leukotriene B4 and nuclear factor-κB, and antiplatelet activity, and large, double-blind clinical studies should be urgently conducted. Expand
Antibacterial activity of polyphenolic compounds isolated from plants of Geraniaceae and Rosaceae families
TLDR
The plants of the families Geraniaceae and Rosaceae offer promise as a source of raw material for isolation of polyphenolic compounds exhibiting bactericidal activity, including against opportunistic pathogens. Expand
Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study
Herbal remedies used by patients for treatment of inflammatory bowel disease include slippery elm, fenugreek, devil’s claw, Mexican yam, tormentil and wei tong ning, a traditional Chinese medicine.Expand
Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials.
TLDR
The data obtained clearly indicate that in the case of peroral use of the examined ellagitannin-rich plant materials the bioactivity of gut microbiota metabolites, i.e. urolithins, has to be taken under consideration. Expand
New triterpenoid saponins from the roots of Potentilla tormentilla
The triterpene fractions of the dried roots of Potentilla tormentilla were investigated and three new compounds were isolated. The new structures were established by detailed nmr spectral studies asExpand
Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells.
TLDR
Potentilla extracts influence on cells of human colon wall lining modulating the main features of them (viability, cytokine production) and as a free radical reducing agents, may be successfully used in the prevention of colon disorders. Expand
...
1
2
3
4
5
...