Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.

@article{Hanson2013TorinsAP,
  title={Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.},
  author={Kirsten K Hanson and Ana S Ressurreiç{\~a}o and Kathrin Buchholz and Miguel Prud{\^e}ncio and Jonathan D Herman-Ornelas and Maria de Lurdes Rebelo and Wandy L. Beatty and Dyann F Wirth and Thomas H{\"a}nscheid and Rui Moreira and Matthias Marti and Maria M Mota},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 30},
  pages={E2838-47}
}
Residence within a customized vacuole is a highly successful strategy used by diverse intracellular microorganisms. The parasitophorous vacuole membrane (PVM) is the critical interface between Plasmodium parasites and their possibly hostile, yet ultimately sustaining, host cell environment. We show that torins, developed as ATP-competitive mammalian target of rapamycin (mTOR) kinase inhibitors, are fast-acting antiplasmodial compounds that unexpectedly target the parasite directly, blocking the… CONTINUE READING