Toremifene improves lipid profiles in men receiving androgen-deprivation therapy for prostate cancer: interim analysis of a multicenter phase III study.

@article{Smith2008ToremifeneIL,
  title={Toremifene improves lipid profiles in men receiving androgen-deprivation therapy for prostate cancer: interim analysis of a multicenter phase III study.},
  author={Matthew Raymond Smith and Stanley Bruce Malkowicz and Franklin M. Chu and John Forrest and Paul R Sieber and Kester G. Barnette and Domingo Rodriquez and Mitchell S. Steiner},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2008},
  volume={26 11},
  pages={1824-9}
}
PURPOSE Androgen-deprivation therapy (ADT) is associated with greater risk of incident coronary heart disease and hospital admission for myocardial infarction; treatment-related increases in serum lipids may contribute to greater cardiovascular disease risk. We evaluated the effects of toremifene, a selective estrogen-receptor modulator, on fasting serum lipid levels in men receiving ADT for prostate cancer. PATIENTS AND METHODS In an ongoing, multicenter, double-blind, placebo-controlled… CONTINUE READING

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