Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone

@article{Forrest2008TorcetrapibinducedBP,
  title={Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone},
  author={Michael Forrest and Dr Ashley Bloomfield and Robert Briscoe and Peter N. Brown and A-M Cumiskey and Juliann Ehrhart and James C. Hershey and Wouter J. Keller and Xutao Ma and Holly E. McPherson and Edmund Messina and Lawrence Peterson and W Sharif-Rodriguez and Peter K. S. Siegl and Pamela Sinclair and Carl P. Sparrow and Andrea S Stevenson and S-Y Sun and C Tsai and Hilda Vargas and Mark Walker and Sean West and Victor White and Richard F Woltmann},
  journal={British Journal of Pharmacology},
  year={2008},
  volume={154},
  pages={1465 - 1473}
}
BACKGROUND AND PURPOSE Inhibition of cholesteryl ester transfer protein (CETP) with torcetrapib in humans increases plasma high density lipoprotein (HDL) cholesterol levels but is associated with increased blood pressure. In a phase 3 clinical study, evaluating the effects of torcetrapib in atherosclerosis, there was an excess of deaths and adverse cardiovascular events in patients taking torcetrapib. The studies reported herein sought to evaluate off-target effects of torcetrapib… CONTINUE READING
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