Torcetrapib: when global risk reduction goes 'off target'.

The major avoidable risks for coronary artery disease (CAD) include hyperlipidaemia, hypertension, obesity, lack of physical exercise, cigarette smoking, depression, excess alcohol intake and, to some extent, diabetes. These overlap with the unavoidable risks of increasing age and male gender. We view this constellation as a ‘global risk’, leading to the… (More)