Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival.

@article{Sundaram2015Tor1SA,
  title={Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival.},
  author={Venkatraghavan Sundaram and Mima Ivanova Petkova and Nuria Pujol-Carrion and Jordi Boada and Maria Angeles de la Torre-Ruiz},
  journal={Molecular microbiology},
  year={2015},
  volume={97 1},
  pages={93-109}
}
Here we show that Mtl1, member of the cell wall integrity pathway of Saccharomyces cerevisiae, plays a positive role in chronological life span (CLS). The absence of Mtl1 shortens CLS and causes impairment in the mitochondrial function. This is reflected in a descent in oxygen consumption during the postdiauxic state, an increase in the uncoupled… CONTINUE READING