Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth.

@article{ZuritaMartinez2005TorAC,
  title={Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth.},
  author={Sara A Zurita-Martinez and Maria Elena Cardenas},
  journal={Eukaryotic cell},
  year={2005},
  volume={4 1},
  pages={63-71}
}
In the budding yeast Saccharomyces cerevisiae, the Tor and cyclic AMP-protein kinase A (cAMP-PKA) signaling cascades respond to nutrients and regulate coordinately the expression of genes required for cell growth, including ribosomal protein (RP) and stress-responsive (STRE) genes. The inhibition of Tor signaling by rapamycin results in repression of the RP genes and induction of the STRE genes. Mutations that hyperactivate PKA signaling confer resistance to rapamycin and suppress the… CONTINUE READING

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