Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: alternative retinoblastoma treatment.

@article{Darsov2012TopotecanVA,
  title={Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: alternative retinoblastoma treatment.},
  author={Denisa Darsov{\'a} and Pavel Pochop and Jiř{\'i} Uhl{\'i}k and Eva Klapkova and Hundie Tesfaye and Daniela Kodetov{\'a} and Jan Lestak and Josef Malis and Luděk Vajner},
  journal={Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia},
  year={2012},
  volume={156 4},
  pages={318-23}
}
AIM To determine intravitreal and plasma concentrations and retinal toxicity after transcorneal intravitreal injection of 1 μg and 2 μg of topotecan (Hycamtin). METHOD Twelve healthy albino rabbits were included in this in vivo experiment. Six anesthetized albino rabbits received a single transcorneal intravitreal injection of 1 μg (group A) or 2 μg (group B) of topotecan. Vitreous and blood samples were collected until 168 h. Left eyes were treated with the same volume of saline. Plasma and… CONTINUE READING

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