Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.

@article{Puppo2008TopotecanIV,
  title={Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.},
  author={Maura Puppo and Florinda Battaglia and Catherine Ottaviano and Silvana Delfino and Domenico Ribatti and Luigi Varesio and Maria Carla Bosco},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 7},
  pages={1974-84}
}
Neuroblastoma produce angiogenic peptides, and the extent of angiogenesis correlates with tumor progression and poor clinical outcome. Hence, angiogenic factor inhibition represents an important therapeutic option. One of the major drives to tumor angiogenesis is hypoxia, a decrease in oxygen tension that characterizes the tumor microenvironment. We investigated the effects of the topoisomerase I inhibitor, topotecan, on vascular endothelial growth factor (VEGF) induction by hypoxia in advanced… CONTINUE READING