Topology of T cell receptor-peptide/class I MHC interaction defined by charge reversal complementation and functional analysis.

@article{Chang1997TopologyOT,
  title={Topology of T cell receptor-peptide/class I MHC interaction defined by charge reversal complementation and functional analysis.},
  author={H C Chang and Alex Smolyar and Rebecca Spoerl and Torsten Witte and Yong Yao and Earl C. Goyarts and Stanley G. Nathenson and Ellis L. Reinherz},
  journal={Journal of molecular biology},
  year={1997},
  volume={271 2},
  pages={278-93}
}
The molecular interactions between the CD8 co-receptor dependent N15 and N26 T cell receptors (TCRs) and their common ligand, the vesicular stomatitis virus octapeptide (VSV8) bound to H-2Kb, were studied to define the docking orientation(s) of MHC class I restricted TCRs during immune recognition. Guided by the molecular surfaces of the crystallographically defined peptide/MHC and modeled TCRs, a series of mutations in exposed residues likely contacting the TCR ligand were analyzed for their… CONTINUE READING
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