Topology mapping of the vacuolar Vcx1p Ca2+/H+ exchanger from Saccharomyces cerevisiae.

@article{Segarra2008TopologyMO,
  title={Topology mapping of the vacuolar Vcx1p Ca2+/H+ exchanger from Saccharomyces cerevisiae.},
  author={Ver{\'o}nica A. Segarra and Lise R Thomas},
  journal={The Biochemical journal},
  year={2008},
  volume={414 1},
  pages={133-41}
}
Saccharomyces cerevisiae uses vacuolar storage to dynamically control the cytoplasmic calcium concentration. Vcx1p, a Ca(2+)/H(+) antiporter and a member of the CAX (Ca(2+)/anion exchanger) family of exchangers, is one of the proteins that sequesters calcium into the vacuole. Although the biological importance of Vcx1p is clear, the molecular mechanism by… CONTINUE READING