Topology-function conservation in protein–protein interaction networks

@inproceedings{Davis2015TopologyfunctionCI,
  title={Topology-function conservation in protein–protein interaction networks},
  author={Darren Davis and Omer Nebil Yaveroglu and No{\"e}l Malod-Dognin and Aleksandar Stojmirovi{\'c} and Natasa Przulj},
  booktitle={Bioinformatics},
  year={2015}
}
MOTIVATION Proteins underlay the functioning of a cell and the wiring of proteins in protein-protein interaction network (PIN) relates to their biological functions. Proteins with similar wiring in the PIN (topology around them) have been shown to have similar functions. This property has been successfully exploited for predicting protein functions. Topological similarity is also used to guide network alignment algorithms that find similarly wired proteins between PINs of different species… CONTINUE READING
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