Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation

@article{Marintchev2009TopologyAR,
  title={Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation},
  author={Assen Marintchev and K. Andy Edmonds and Boriana Marintcheva and Elthea Hendrickson and Monika Oberer and Chikako Suzuki and Barbara Herdy and Nahum Sonenberg and Gerhard Wagner},
  journal={Cell},
  year={2009},
  volume={136},
  pages={447-460}
}
The RNA helicase eIF4A plays a key role in unwinding of mRNA and scanning during translation initiation. Free eIF4A is a poor helicase and requires the accessory proteins eIF4G and eIF4H. However, the structure of the helicase complex and the mechanisms of stimulation of eIF4A activity have remained elusive. Here we report the topology of the eIF4A/4G/4H helicase complex, which is built from multiple experimentally observed domain-domain contacts. Remarkably, some of the interactions are… CONTINUE READING