Topologically conserved residues direct heme transport in HRG-1-related proteins.

@article{Yuan2012TopologicallyCR,
  title={Topologically conserved residues direct heme transport in HRG-1-related proteins.},
  author={Xiaojing Yuan and Olga Protchenko and Caroline C. Philpott and Iqbal Hamza},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 7},
  pages={4914-24}
}
Caenorhabditis elegans and human HRG-1-related proteins are conserved, membrane-bound permeases that bind and translocate heme in metazoan cells via a currently uncharacterized mechanism. Here, we show that cellular import of heme by HRG-1-related proteins from worms and humans requires strategically located amino acids that are topologically conserved across species. We exploit a heme synthesis-defective Saccharomyces cerevisiae mutant to model the heme auxotrophy of C. elegans and demonstrate… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Multiple Hrg-1 Paralogs Regulate Heme Homeostasis in C . Elegans

Ben Saidan
2014
View 10 Excerpts
Highly Influenced

Heme acquisition in the parasitic filarial nematode Brugia malayi

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2016
View 19 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Similar Papers

Loading similar papers…