Topologically conserved residues direct heme transport in HRG-1-related proteins.

  title={Topologically conserved residues direct heme transport in HRG-1-related proteins.},
  author={Xiaojing Yuan and Olga Protchenko and Caroline C. Philpott and Iqbal Hamza},
  journal={The Journal of biological chemistry},
  volume={287 7},
Caenorhabditis elegans and human HRG-1-related proteins are conserved, membrane-bound permeases that bind and translocate heme in metazoan cells via a currently uncharacterized mechanism. Here, we show that cellular import of heme by HRG-1-related proteins from worms and humans requires strategically located amino acids that are topologically conserved across species. We exploit a heme synthesis-defective Saccharomyces cerevisiae mutant to model the heme auxotrophy of C. elegans and demonstrate… CONTINUE READING

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