Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma

  title={Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma},
  author={Hatylas Azevedo and Carlos Alberto Moreira-Filho},
  journal={Scientific Reports},
Biological networks display high robustness against random failures but are vulnerable to targeted attacks on central nodes. Thus, network topology analysis represents a powerful tool for investigating network susceptibility against targeted node removal. Here, we built protein interaction networks associated with chemoresistance to temozolomide, an alkylating agent used in glioma therapy, and analyzed their modular structure and robustness against intentional attack. These networks showed… 
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