Topological potential of zwitterion analogues of cimetidine as H2 receptor antagonists.

Abstract

Topological potential of zwitterionic analogues of cimetidine as H2 receptor antagonists have been investigated using a number of topological indices viz. molecular redundancy index (MRI), first order molecular connectivity index (1chiV) and rooted Wiener (Ww) and rooted Szeged (Szw) indices. The multiple regression analysis have indicated that the H2 receptor antagonist activities (-logKB) can be modelled using indicator parameters. Most significant results were obtained when MRI was coupled with Ww as well as the indicator parameters (Ip1 and Ip2).

Cite this paper

@article{Agrawal2000TopologicalPO, title={Topological potential of zwitterion analogues of cimetidine as H2 receptor antagonists.}, author={Vijay K. Agrawal and Sarika Sachan and Padmakar V. Khadikar}, journal={Polish journal of pharmacology}, year={2000}, volume={52 1}, pages={39-46} }