Topological mechanisms involved in the formation of clathrin-coated vesicles.

  title={Topological mechanisms involved in the formation of clathrin-coated vesicles.},
  author={Albert J Jin and Ralph J Nossal},
  journal={Biophysical journal},
  volume={65 4},
By examining the basic characteristics of clathrin lattices, we discover that simple topological rules impose strict constraints on clathrin lattice transformations. These constraints require that internal bond rearrangements take place in conjunction with the addition or removal of pairs of clathrin triskelions within the interior of existing clathrin lattice patches. Similar constraints also are relevant to coated-vesicle shape changes and their budding-off from pit lattices. Via specific… CONTINUE READING

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