Topological localization of the human transcription factors IIA, IIB, TATA box-binding protein, and RNA polymerase II-associated protein 30 on a class II promoter.

@article{Coulombe1994TopologicalLO,
  title={Topological localization of the human transcription factors IIA, IIB, TATA box-binding protein, and RNA polymerase II-associated protein 30 on a class II promoter.},
  author={Benoit Coulombe and Jie Li and Jack Greenblatt},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 31},
  pages={
          19962-7
        }
}
The human general transcription factors IIA and IIB bind directly to the TATA box-binding protein (TBP), and modulate transcription initiation by RNA polymerase II. RAP30, the small subunit of TFIIF, binds to TFIIB and RNA polymerase II and recruits RNA polymerase II to a preinitiation complex containing TBP and TFIIB. By using the adenovirus 2 major late promoter tagged site-specifically with the photoactivatible cross-linking reagent N3R-dUMP we have localized TBP, two subunits of TFIIA (A35… CONTINUE READING

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The general transcription machinery and general cofactors.

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