Topological domain structure of the Escherichia coli chromosome.

@article{Postow2004TopologicalDS,
  title={Topological domain structure of the Escherichia coli chromosome.},
  author={Lisa Postow and Christine D. Hardy and Javier Arsuaga and Nicholas R. Cozzarelli},
  journal={Genes & development},
  year={2004},
  volume={18 14},
  pages={
          1766-79
        }
}
The circular chromosome of Escherichia coli is organized into independently supercoiled loops, or topological domains. We investigated the organization and size of these domains in vivo and in vitro. Using the expression of >300 supercoiling-sensitive genes to gauge local chromosomal supercoiling, we quantitatively measured the spread of relaxation from double-strand breaks generated in vivo and thereby calculated the distance to the nearest domain boundary. In a complementary approach, we… CONTINUE READING

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