Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

  title={Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.},
  author={Wafik S El-Deiry and Takashi Tokino and Todd Waldman and J D Oliner and Victor E. Velculescu and Marilee Burrell and David E Hill and Eugene Healy and Jonathan Laurence Rees and Stanley R. Hamilton},
  journal={Cancer research},
  volume={55 13},
The p53-regulated gene product p21WAF1/CIP1 is the prototype of a family of small proteins that negatively regulate the cell cycle. To learn more about p21WAF1/CIP1 regulation in vivo, monoclonal antibodies were developed for immunohistochemistry. These revealed that p21WAF1/CIP1 expression followed radiation-induced DNA damage in human skin in a pattern consistent with its regulation by p53. A detailed comparison of the human, rat, and mouse p21WAF1/CIP1 promoter sequences revealed that this… CONTINUE READING

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